N-methyl-D-aspartate receptor antibody production from germinal center reactions: Therapeutic implications
نویسندگان
چکیده
منابع مشابه
Combined Therapy for Anti-N-methyl D-aspartate Receptor Encephalitis
Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained ps...
متن کاملPersistent intrathecal antibody synthesis 15 years after recovering from anti-N-methyl-D-aspartate receptor encephalitis.
BACKGROUND Anti- N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disorder characterized by high intrathecal antibody synthesis. Little is known about the long-term follow-up of the cerebrospinal fluid antibody status. OBJECTIVE To describe persistent intrathecal antibody synthesis in a clinically healthy person 15 years after recovering from anti-NMDAR encephalitis. ...
متن کاملAdjunct therapeutic plasma exchange for anti-N-methyl-D-aspartate receptor antibody encephalitis: a case report and review of literature.
Encephalitis associated with autoantibodies directed against the N-methyl-D-aspartate receptor (NMDAR) is usually a paraneoplastic syndrome that presents in young females with ovarian teratomas. We report a case of a previously healthy 14-year-old girl with sudden-onset paranoia, hallucinations, hyperactivity, increased speech, decreased sleep, seizures, and violent behavior deteriorating to ca...
متن کاملAcid tests of N-methyl-D-aspartate receptor gating basics.
In this issue of Molecular Pharmacology, Low et al. (2003) delve into the mechanisms by which pH modulates the glutamate receptor subtype specifically activated by N–methylD-aspartate (NMDA). Based on a combination of scanning mutagenesis, patch clamp physiology, and molecular modeling, the authors conclude that amino acids involved in NMDA receptor modulation by protons are clustered in region...
متن کاملPediatric anti-N methyl D aspartate receptor encephalitis
Anti-N Methyl D Aspartate Receptor encephalitis (anti-NMDARE) is a recently defined disease, which is probably more under-recognized than rare. We report a case of anti-NMDARE in a 13-years-old girl, who presented with intractable seizures. To the best of our knowledge, this is the second case of pediatric anti-NMDARE being reported from India. The need for a greater awareness of this disease a...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2018
ISSN: 0364-5134
DOI: 10.1002/ana.25173